The two Spanish giants have already met on three occasions this season, twice in the last fortnight, and with both clubs reaching the business end of the campaign, officials believe the match could be at risk of crowd trouble.
The Madrid government met up with officials from the local police, representatives from the health service, UEFA delegates and the person in charge of safety at the Bernabeu on Tuesday afternoon to discuss the matter.
"All access through doors at the Bernabeu will be strictly monitored to prevent people bringing in any objects, whatever size that goes against the Healthy and Safety Act for sports stadiums," Madrid politician Maria Dolores Carrion told reporters.
Plaza de Cibeles will also be strictly monitored throughout the evening with everyone involved with providing a safe environment for supporters hoping for an uneventful evening off the pitch.
Madrid supporters earned praise from Carrion who applauded their "good civic behaviour" at Cibeles after the club's Copa del Rey success last Wednesday.
Hours before the game, a large contingent of police will be making sure that Barcelona supporters arrive in the city safely and will also monitor the likely meeting places of both sets of fans.
